Preparation and characterization of topical solid lipid nanoparticles containing deferoxamine

Introduction: Deferoxamine mesylate increases hypoxia inducible factor-1 alpha transactivation by preventing iron-catalyzed reactive oxygen stress, so it can be used to improve diabetic ulcer healing. This study was undertaken develop and physicochemical properties of topical deferoxamine-loaded solid lipid nanoparticles.
 Method: Solid nanoparticles were prepared using cold homogenization technique full factorial design evaluate the effect surfactant type amount lipid. In-vitro characterization formulations including particle size distribution, thermal behavior Differential Scanning Calorimetry, entrapment efficiency, release profile carried out.
 Results: The results showed an acceptable range (2.88–174 nm), a narrow average 60% for drug efficiency which is significant hydrophilic drug. from initial burst followed slow prolonged manner. Calorimetry also confirmed obtained loading evaluations. best formulation had high level lowest rate contained compritol oleic acid in 8% total formula, as well tween 80 lecithin mixture surfactants.
 Conclusions: demonstrated deferoxamine could loaded deliver topically.